Identification of Novel Targetable Kinases in SR-a GvHD

University of Freiburg

Status: Completed

Conditions: Graft Versus Host Disease

Study type: Observational

Funder types: Other

Identifiers

NCT04342442

KIN-SR-GvHD

Details and patient eligibility

About

In this study, the investigators aim to identify novel targetable kinases in SR-a GvHD patient samples and investigate their role in different immune cell subtypes.

Full description

Corticosteroids are the first-line treatment of a GvHD, however many patients do not respond to corticosteroids. Patients with steroid-refractory a GvHD (SR-a GVHD) have a low 1-year survival rate. In this study, the investigators aim to identify and validate novel targetable kinases in SR-a GvHD patient peripheral blood mononuclear cells (PBMCs) by using a kinase-specific proteomic approach, and thereafter to investigate the role of the identified kinases in different immune cell subtypes by analyzing biopsies taken from SR- a GvHD patients.

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• allo-transplanted
• confirmed diagnosis of a GvHD
• age ≥ 18 years
• peripheral blood samples and biopsies available
• written informed consent
• ability to understand the nature of the study and the study-related procedures and to comply with them

Exclusion criteria

• age < 18 years
• lack of informed consent
• patients that cannot be classified in one of the 2 groups (steroid-refractory, steroid-responsive)

Trial design

24 participants in 2 patient groups

Steroid-refractory a GvHD

Description:

Analysis of peripheral blood and intestinal biopsies of patients suffering from steroid-refractory a GvHD

Steroid-responsive a GvHD

Description:

Analysis of peripheral blood and intestinal biopsies of patients suffering from steroid-responsive a GvHD