Identification of Novel Targets for Regulation of Adipose Tissue Mass

Gottfried Rudofsky

Status: Completed

Conditions: Obesity

Treatments: Dietary Supplement: Optifast

Study type: Interventional

Funder types: Other

Identifiers

NCT00773565

EFSD-CRP-2008

Details and patient eligibility

About

The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.

Enrollment: 62 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants of the OPTIFAST52 program
• BMI > 30 kg/m2

Exclusion criteria

• Rejection of informed consent by the participant

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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62 participants in 1 patient group

Optifast

Other group

Description:

Patients included take part at a weight reduction program over one year.

Treatment:

Dietary Supplement: Optifast