Identification of Viral Variants Involved in the Transmission of Hepatitis C and Characterization of Antigenic and Functional Properties of Their Envelope Glycoproteins (VINTAGE VHC)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Hepatitis C

Treatments: Procedure: Blood sample (act specific of blood withdrawal for the study)

Study type: Interventional

Funder types: Other

Identifiers

NCT02574884

AORT10-DB / VINTAGE VHC

Details and patient eligibility

About

The study consists to Identify viral variants involved in the transmission of hepatitis C and characterize the antigenic and functional properties of their envelope glycoproteins at very early stage of infection (before seroconversion).

Enrollment: 8 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 years
• agree to participate in this study (signing the consent form or information form signed and letter of no objection for subjects contaminated by blood exposure).

These criteria are specific to contaminated subjects:

• primary infection before development of HCV antibody (seroconversion): nucleic acid testing positive in the absence of HCV antibodies.

These criteria are specific to individual sources :

• HCV antibody positive.

Exclusion criteria

• refusal to participate
• private about freedom
• under guardianship
• under justice
• minor or major person unable to consent

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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8 participants in 3 patient groups

Recently infected subjects

Other group

Description:

Actual population of blood donors primo-infected with HCV with specific intervention for the study : one blood sample during the inclusion visit

Treatment:

Procedure: Blood sample (act specific of blood withdrawal for the study)

Retrospective cases

No Intervention group

Description:

Population of infected blood donors in 2007, 2008 and 2009 No blood sample

Individuals sources

Other group

Description:

Specific intervention for the study : one blood sample during the inclusion visit

Treatment:

Procedure: Blood sample (act specific of blood withdrawal for the study)