Identifying Biomarkers for Endothelial Dysfunction in Women With Preeclampsia (DAISY)

Antwerp University Hospital (UZA)

Status: Enrolling

Conditions: Preeclampsia; Endothelial Function (FMD); Retinal Vessels

Treatments: Other: Dynamic retinal vessel analyzer; Other: Arterial stiffness; Other: Flow-meditad dilatation

Study type: Interventional

Funder types: Other

Identifiers

NCT07084727

7765

Details and patient eligibility

About

Every pregnancy has a major impact on a woman's heart and blood vessels due to changes required by the body to maintain proper blood flow between mother and foetus. When the placenta does not work properly, preeclampsia can occur. An important first symptom is high blood pressure. Women who have experienced preeclampsia are at higher risk of developing blood pressure and heart problems later on. Therefore, it is very important to detect changes in the blood vessel system so that they can be treated promptly and correctly. We aim to do this by using a new, non-invasive eye test that examines the blood vessels of the retina.

Enrollment: 60 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• at least 18 years old
• willing to undergo vascular assessments
• informed consent signed

Exclusion criteria

• Unwilling to provide informed consent
• Open-angle glaucoma
• Epilepsia
• (gestational) Diabetes
• Multiple pregnancies
• Fetal malformations
• Hypercholesterolemia
• Kidney disease
• Auto-immune disorders
• Connective tissue diseases

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

Interventional group

Other group

Description:

All patients in this study will undergo all vascular assessments including pulse wave velocity, pulse wave analysis, flow-mediated dilation, fundus photography and dynamic retinal vessel analysis.

Treatment:

Other: Flow-meditad dilatation

Other: Arterial stiffness

Other: Dynamic retinal vessel analyzer