Identifying Characteristic Signature of Attention Deficit / Hyperactivity Disorder (ADHD) and Ritalin Treatment

Hadassah Medical Center

Status: Unknown

Conditions: "Attention Deficit Hyperactivity Disorder"

Treatments: Drug: Ritalin; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01962181

RE0379-HMO-STILL

Details and patient eligibility

About

In this study we try to identify the signature of brain activity in the EEG of attention deficit disorder (ADHD) patients compared to healthy subjects under different doses of Ritalin (methylphenidate) treatment.

Full description

In this study we try to identify the signature of brain activity in the EEG of attention deficit disorder (ADHD) patients compared to healthy subjects under different doses of Ritalin (methylphenidate) treatment. All subjects will undergo 1-4 EEG sessions. In each session we will use a different dose of Ritalin or placebo. A detailed neuropsychological tests will be done during the EEG recording. A powerful machine-learning techniques will be used in order to find a specific signature of ADHD and Ritalin treatment in the EEG recording.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects, aged 18-50 years.
• Subjects aged 18-50 years diagnosed with ADHD and treated with Ritalin regularly (at least once a week).

Exclusion criteria

• Patients previously diagnosed as suffering from a brain disease except for ADHD.
• Patients after traumatic head injury.
• Patients who are unable to express their consent to participate in the study.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups, including a placebo group

Ritalin

Active Comparator group

Description:

Ritalin treatment at different doses

Treatment:

Drug: Ritalin

Placebo

Placebo Comparator group

Description:

Two meetings, one of which will be given a placebo and the other will be given a low dose of Ritalin, randomly.

Treatment:

Drug: Placebo