Identifying Molecular Determinants of Infertility in Men (MODIFY)

Institute for Human Development and Potential (IHDP), Singapore

Status

Completed

Conditions

Male Infertility

Study type

Observational

Funder types

Other

Identifiers

NCT06147700

2023-085

Details and patient eligibility

About

The purpose of this study is to understand the underlying mechanisms of infertility caused by unknown factors. The investigator propose to identify small non-coding RNA (sncRNA) biomarkers of infertility and advance towards developing a more accurate and robust approach for infertility diagnosis.

Full description

The goal of the study is to identify small non-coding RNA signatures of infertility in men through the comparison of sperm sncRNA profiles from around 100 men (21-50 years of age). The participants will be classified into fertile and infertile groups by the conventional method.

Through the project, the investigator intends to understand the underlying mechanisms of idiopathic infertility. By utilizing semen as liquid biopsy, through sperm sncRNA profiling and comparison (infertile vs fertile). The investigator proposes to identify the sncRNA (miRNAs, piRNAs and tRFs) as biomarkers of infertility.

The investigator proposes to generate a validated signature of sncRNAs that will help in selecting high quality sperms for IVF.

Enrollment

100 patients

Sex

Male

Ages

21 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Male, aged 21 - 50 years old
Proficient in English language
Willing to comply to study protocol
Able to provide written informed consent

Exclusion Criteria

Current and/or previous diagnosis of Tuberculosis, Acquired immunodeficiency syndrome (AIDs), and other sexually transmitted diseases
Experiencing severely limited mobility (eg. Wheelchair bound, need walking aid)
Diagnosed with severe unstable mental conditions (eg. Dementia, or cognitive impairment)
Alcohol or drug abuse