Idiopathic Pulmonary Fibrosis Job Exposures Study (IPFJES)

Imperial College London

Status: Completed

Conditions: IPF; Idiopathic Pulmonary Fibrosis

Treatments: Other: Computer-assisted telephone interview; Genetic: Genetic analysis

Study type: Observational

Funder types: Other

Identifiers

NCT03211507

16SM3627

Details and patient eligibility

About

A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.

Full description

Idiopathic pulmonary fibrosis (IPF) is a scarring lung disease. It damages the air sacs that allow oxygen to be transferred into the blood and transported to vital organs. These changes make people with IPF cough and feel short of breath. It not known what causes the damage. People who get IPF are usually older than 40; it's a very serious illness that cannot be cured and gets worse over time. Statistics show that IPF is becoming more common in the UK but it's not known why. It can be difficult for doctors to tell if someone has IPF or another disease called asbestosis.

Enrollment: 960 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

For cases

Inclusion Criteria:

• New diagnosis of IPF between February 2017 and October 2019

Exclusion Criteria:

• Unable to give informed consent
• Ever worked outside of the UK

For controls

Inclusion Criteria:

• New outpatient department attendee between February 2017 and October 2019

Exclusion Criteria:

• Unable to give informed consent
• Ever worked outside of the UK (does not include work outside the UK by members of the armed forces or merchant navy)
• Diagnosis of IPF

Trial design

960 participants in 2 patient groups

Case

Description:

Males with an incident diagnosis of IPF made between the 1st of February 2017 and the 5th of October 2019.

Treatment:

Other: Computer-assisted telephone interview

Genetic: Genetic analysis

Controls

Description:

Males with an incident hospital outpatient attendance between the 1st of February 2017 and the 5th of October 2019 who do not have a diagnosis of IPF. At each participating centre a control clinic is randomly selected from all control clinics that the research team is able to recruit from; this clinic is the source clinic for controls for the duration of the study.

Treatment:

Other: Computer-assisted telephone interview

Genetic: Genetic analysis