If Chronic Gallbladder Diseases Increase the Incidence of PEC

Hepatopancreatobiliary Surgery Institute of Gansu Province

Status

Completed

Conditions

Cholecystitis

Treatments

Procedure: ERCP

Study type

Observational

Funder types

Other

Identifiers

NCT04242394

Chronic gallbladder disease

Details and patient eligibility

About

This is a prospective, multi-centre trial conducts at 4 ERCP centers in China designed to determine if chronic gallbladder diseases increase the incidence of Post-Endoscopic Retrograde Choledochopancreatography-Choledocholithiasis (PEC)

Full description

Endoscopic Retrograde Choledochopancreatography(ERCP) has the advantages of less injury and faster recovery for common bile duct stone patients. However, according to our retrospective study, ERCP will has a mostly 10% possibility to get an acute purulent cholecystitis which often requires emergency intervention, when patients combined with chronic gallbladder diseases, such as chronic cholecystitis, asymptomatic gallstones, and gallbladder wall thickness, the incidence of PEC will increase accordingly. The aim of this study is to observe if chronic gallbladder disease will increase the occurence of PEC and develop a high-risk PEC model.

Enrollment

1,019 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

ERCP patients with gallbladder in situ

Exclusion criteria

Acute cholecystitis before surgery
Gallbladder has been removed
Gastrointestinal reconstruction
Unwillingness or inability to consent for the study
Unstable vital signs Coagulation dysfunction (INR>1.5)
Low peripheral blood platelet count (<50×10 ^9 / L) or using anti-coagulation drugs
Preoperative coexistent diseases: acute pancreatitis, GI tract hemorrhage, severe liver disease (such as decompensated liver cirrhosis, liver failure and so on), septic shock Biliary- duodenal fistula confirmed during ERCP
Pregnant women or breastfeeding