IgE-mediated Allergies Among Type 1 Diabetes Mellitus Children, Single Centre Observational Study

Mansoura University Children Hospital

Status: Completed

Conditions: Diabetic Children

Treatments: Diagnostic Test: skin prick test

Study type: Observational

Funder types: Other

Identifiers

NCT05596656

MS/17.07.21

Details and patient eligibility

About

an interviewer-administrated questionnaire was designed to take history of allergy in diabetic child come to outpatient clinic fulfilling inclusion criteria and used to collect data. Skin prick testing was performed to all diabetic children with history of allergy. Laboratory assessment of Serum Total IgE, IL5 and eosinophils%.

Enrollment: 90 patients

Sex: All

Ages: 2 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children with at least 2 Years duration of diabetes diagnosed by Criteria for the diagnosis of diabetes mellitus (ISPAD 2018) that include:
• Classic symptoms of diabetes or hyperglycemic crisis, with plasma glucose concentration ≥11.1 mmol/L (200 mg/dL).
• Fasting plasma glucose ≥7.0 mmol/L (≥126 mg/dL). Fasting is defined as no caloric intake for at least 8 hours.
• Two-hour post load glucose ≥11.1 mmol/L (≥200 mg/dL) during an oral glucose tolerance test (OGTT).
• HbA1c ≥6.5%.

Exclusion criteria

• presence of other chronic disease associated with DM.

Trial design

90 participants in 2 patient groups

allergic type 1 DM children

Description:

45 cases were considered allergic based on written questionnaire taken by the resident. Diagnosis of atopy was confirmed by skin prick testing

Treatment:

Diagnostic Test: skin prick test

Non-allergic type 1 DM children

Description:

Forty-five Non-allergic type 1 DM children were selected as age and sex matched control group.

Treatment:

Diagnostic Test: skin prick test