IgY Efficacy on Periodontitis Patients

Immunology Research Institute in Gifu

Status: Completed

Conditions: Chronic Periodontitis

Treatments: Dietary Supplement: Placebo IgY; Dietary Supplement: lozenges containing IgY

Study type: Interventional

Funder types: Industry; Other

Identifiers

NCT02705885

RHM 14

Details and patient eligibility

About

Patients visiting National Hospital of Odonto-Stomatology for treating periodontitis used a food supplement (lozenge) containing chicken egg antibody (IgY) against Porphyromonas gingivalis gingipains as an adjunct to conventional scaling and root planing (SRP). After 8 weeks the patients were examined against. Parameters including probing depth (PD), bleeding on probing (BOP), number of P. gingivalis in periodontal pockets were evaluated and compared to the control group that had used placebo lozenges.

Enrollment: 60 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients diagnosed with chronic periodontitis
• had at least 2 interproximal site with pocket depth between 3 mm to 5 mm
• nonsmokers with at least 20 natural teeth
• bone loss and bleeding on probing
• had not undergone periodontal treatments within 6 weeks before the study

Exclusion criteria

• patients received medication such as antibiotics or anti-inflammatory drugs within the previous 3 months
• had allergy to egg proteins

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

Gingipain IgY

Experimental group

Description:

Participants consume lozenges containing IgY against gingipains of Porphyromonas gingivalis

Treatment:

Dietary Supplement: lozenges containing IgY

Placebo IgY

Placebo Comparator group

Description:

Participants consume lozenges containing placebo IgY

Treatment:

Dietary Supplement: Placebo IgY