IL-33, Endocan and Endothelial Cells

University Hospital, Lille

Status: Withdrawn

Conditions: Endothelial Cell

Study type: Observational

Funder types: Other

Identifiers

NCT03984383

2018-A03087-48 (Other Identifier)

2017_13

Details and patient eligibility

About

The study aims to investigate the inflammatory response of endothelial cells to various stimulations, in particular the production of IL33 and of endocan in response to allergens, agonists of microorganisms and pollutants.

For that purpose, this project attempts to set up a biological collection of lung and umbilical cord endothelial cells.

Lung endothelial cells are resected from a surgical specimen, resulting from a lung cancer surgery.

Umbilical cord-derived endothelial cells are taken from the umbilical cord collected during the delivery.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• signed consent
• Pregnant woman for umbilical cord-derive-endothelial cells

Exclusion criteria

• Age < 18 years

• Refusal to participate to the study

• Endothelial cord-drived endothelial cells :

  • significant materno-foetal disorder (for example: meconium-stained amniotic fluid, chorioamnionitis, placental thrombosis, eclampsia etc.)
  • infection for HIV, VHB, VHC
  • unknown status for HIV, VHB, VHC the day of the childbirth.

Trial design

0 participants in 2 patient groups

Lung-derived endothelial cells

Description:

Every patient of more than 18 years undergoing lung cancer surgery in the department of thoracic surgery of the University Hospital of Lille.

Umbilical cord-derived endothelial cells

Description:

Every patient of more than 18 years giving birth in the University Hospital of Lille in the absence of significant materno-foetal disorder (for example: meconium-stained amniotic fluid, chorioamnionitis, placental thrombosis, eclampsia etc.) or of infection for HIV, VHB, VHC or if unknown status for HIV, VHB, VHC the day of the childbirth.