IL-35+Breg/Il-35 Effect on T Cell Immune in Patients With CHB

Naval Military Medical University

Status: Completed

Conditions: Chronic Hepatitis b

Study type: Observational

Funder types: Other

Identifiers

NCT03734783

16ZR1400400

Details and patient eligibility

About

The investigators observed the level of IL-35 secreting B regulatory (IL-35+Bregs) cells in peripheral blood cells in patients with chronic hepatitis B, and analysed the relationship between the IL-35+Bregs level and disease stage, and Th1 and Th2 cells level.

Full description

Regulatory B cells (Bregs) are involved in the immune tolerance process through multiple pathways and Bregs are involved in the process of chronic HBV infection.

Here the investigators intended to investigate the regulating role and the mechanism of CD19+ IL-35+ cells on host T cell immune during chronic HBV infection by using in vitro cell sorting, B cell differentiation induction, Transwell cell co-culture system and other methods.

Enrollment: 55 patients

Sex: All

Ages: 17 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of chronic hepatitis B virus infection
• 17<age<70
• Can read, understand and sign patients informed consent

Exclusion criteria

• Co-infection with HCV,HIV,HDV etc.
• Have malignancy
• Have uncontrollable extra-hepatic disease

Trial design

55 participants in 2 patient groups

Patients

Description:

HBsAg positive more than 6 months

health control