Illuminating New Paths in the Treatment of Multiple Sclerosis Relapses - Early and Specialized Rehabilitation (MS_Early_Rehab)

Lars Hvid

Status and phase: Enrolling; Phase 2

Conditions: Multiple Sclerosis

Treatments: Behavioral: Usual care; Behavioral: Intensive rehab

Study type: Interventional

Funder types: Other

Identifiers

NCT06956326

MS_Early_Rehab

Details and patient eligibility

About

The overall purpose of this project is to develop and test an infrastructure that can ensure early and specialized rehabilitation for individuals with multiple sclerosis (MS) on their path to recovery from a relapse. If this project proves successful, it can therefore help optimize clinical practice and provide a significant contribution to the treatment of relapsing-remitting sclerosis.

Enrollment: 64 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• admitted to the Danish MS Hospitals for an inpatient rehabilitation stay
• confirmed motor relapse (within the past 6 months) by a neurologist, with disability/ functional interference characterized by change in pyramidal, and/or cerebellar functional scores of 2 or higher
• completed steroid or other acute relapse treatment, if prescribed
• age over 18 years

Exclusion criteria

• more than 6 months since onset of motor relapse
• medical conditions or substantial cognitive impairments that hinder participation in the study (e.g. inability to perform or understand the intensive rehabilitation)
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

64 participants in 2 patient groups

Intensive rehab

Experimental group

Description:

10 weeks of community-based physical therapy. Participants will receive two weekly supervised physical therapy session (45-60 minutes). The content of this exercise program and the specific exercises and exercise methods will be planned in collaboration between MS specialists from the Danish MS hospitals, the local physical therapist, and the participant.

Treatment:

Behavioral: Intensive rehab

Usual care

Active Comparator group

Description:

10 weeks of usual care physiotherapy, normally comprised of municipal rehabilitation as well as self-administered behavior.

Treatment:

Behavioral: Usual care