Image Enhanced Endoscopy IBD

Royal Perth Hospital

Status: Enrolling

Conditions: Dysplasia; Inflammatory Bowel Diseases

Treatments: Procedure: Image Enhanced Endoscopy Filters

Study type: Interventional

Funder types: Other

Identifiers

NCT06266104

Protocol V1.4_04012024

Details and patient eligibility

About

Dye- spray chromoendoscopy remains the recommended gold standard approach for IBD dysplasia surveillance colonoscopy however recently published European and American guidelines recommend either dye-spray or virtual chromoendoscopy can be used for surveillance. The newer Imaged Enhanced Endoscopy technologies TXI and LCI have not formally been evaluated in IBD surveillance in a randomised controlled trial setting. These modes can easily be applied during colonoscopy and if demonstrated to be effective may save time and eliminate the need for dye-spray chromoendoscopy in the future.

Enrollment: 270 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with inflammatory bowel disease aged 18 to 75 years, that meet Australian recommendations to undergo surveillance colonoscopy will be identified and invited participate in the study.

Exclusion criteria

• Any active disease
• Inadequate bowel preparation
• Previous surgical resection involving the colon
• History of bowel cancer

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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270 participants in 3 patient groups, including a placebo group

Dye Spray Chromoendoscopy

Placebo Comparator group

Description:

Patients undergoing surveillance with dye spray chromoendoscopy

Treatment:

Procedure: Image Enhanced Endoscopy Filters

TXI

Active Comparator group

Description:

Patients undergoing surveillance with TXI (Texture and Colour Enhancement Imaging)

Treatment:

Procedure: Image Enhanced Endoscopy Filters

LCI

Active Comparator group

Description:

Patients undergoing surveillance with LCI (Linked Colour Imaging )

Treatment:

Procedure: Image Enhanced Endoscopy Filters