Image Guided Radiation Therapy For Prostate Cancer

Gustave Roussy

Status and phase: Completed; Phase 3

Conditions: Prostate Cancer

Treatments: Procedure: Standard imaging; Procedure: Control position by 3DOBI before the fraction

Study type: Interventional

Funder types: Other

Identifiers

NCT00433706

CSET 1248

IGRT-P

Details and patient eligibility

About

During the 7 to 8 weeks of conformal radiotherapy for prostate carcinoma, the prostate has an intra-pelvic motion which is not detectable by the conventional portal imaging. This prostate motion may lead to a mistargeting, which possibly decreases the local control. On the other hand, the new 3D on board imaging (3D OBI) allows to localize the target but is expensive. The cost/effectiveness ratio is not well established, as well as the frequency of using such imaging during the course of radiation.

Enrollment: 470 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

• prostate adenocarcinoma
• intermediate / high risk group
• N0 or N -
• treatment by conformal radiotherapy (including or not IMRT), with or without androgen deprivation

Exclusion criteria

• pelvic irradiation
• metal objects in the pelvis

Trial design

470 participants in 2 patient groups

Control position by 3DOBI daily

Experimental group

Treatment:

Procedure: Control position by 3DOBI before the fraction

Standard imaging

Active Comparator group

Treatment:

Procedure: Standard imaging