Image-guided Thermal Ablation vs. Lobectomy for Solitary Papillary Thyroid Microcarcinoma

Chinese PLA General Hospital (301 Hospital)

Status: Completed

Conditions: Papillary Thyroid Cancer

Treatments: Procedure: thyroid lobectomy; Procedure: image-guided thermal ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT06325787

S2021-211-02

Details and patient eligibility

About

To evaluate the clinical outcomes of image-guided thermal ablation versus thyroid lobectomy for the treatment of papillary thyroid microcarcinoma

Enrollment: 1,021 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. solitary papillary thyroid carcinoma confirmed by fine-needle aspiration or core-needle biopsy;
2. largest diameter ≤10 mm;
3. no evidence of extrathyroidal extension( no signs of unsmooth thyroid capsule or involvement of the perithyroidal tissue) on ultrasound;
4. no evidence of cervical lymph node metastasis on US or neck CT;
5. no distant metastasis on chest CT;
6. no history of neck irradiation.

Exclusion criteria

• (1)aggressive subtype of papillary thyroid microcarcinoma confirmed by biopsy(1); (2)multiple tumors; (3) incomplete data or lost follow-up

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,021 participants in 2 patient groups

lobectomy

Active Comparator group

Description:

thyroid lobectomy, is recommended as first-line treatment for papillary thyroid micraocarcinima

Treatment:

Procedure: thyroid lobectomy

image-guided thermal ablation

Experimental group

Description:

radiofrequency ablation or microwave ablation

Treatment:

Procedure: image-guided thermal ablation