Image Quality and Radiation Dose Associated With Cardiac Scans in Modern CT Scanners

University Hospital Augsburg

Status: Not yet enrolling

Conditions: Coronary Artery Disease

Treatments: Diagnostic Test: Cardiac CTA on a photon-counting detector CT (PCD-CT); Diagnostic Test: Cardiac CTA on a regular CT with Energy-Integrating Detector (EID-CT)

Study type: Observational

Funder types: Other

Identifiers

NCT05245149

21-0383

Details and patient eligibility

About

The main objective of this study is to evaluate the dose efficiency of coronary CT angiography (CTA) using a photon counting detector CT (PCD-CT) with the dose efficiency of coronary CT angiography of prior CT generations. 100 patients with a clinical indication for coronary CT angiography will be prospectively enrolled and undergo coronary CTA on a PCD-CT. For comparison, a matched retrospective cohort of 100 patients will be created who had undergone on a prior scanner generation (retrospective cohort).

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• indication for coronary CTA confirmed by board-certified radiologist ('justified indication' according to German/European radiation protection law) AND
• patient (is able to give informed consent and) has given informed consent.

Exclusion criteria

• contraindications to (iodine based) iv contrast material: known allergy to iodine-based iv contrast, acute or high-grade chronic kidney insufficiency with an estimated glomerular filtration rate < 30 ml/min/1.73 m², latent or manifest hyperthyroidism
• known or suspected pregnancy
• lactating mothers

Trial design

200 participants in 2 patient groups

Prospective Cohort

Description:

Patients with a clinical indication for coronary CT angiography will undergo this scan on a photon counting detector CT (PCD-CT).

Treatment:

Diagnostic Test: Cardiac CTA on a photon-counting detector CT (PCD-CT)

Retrospective Cohort

Description:

For comparison, a matched retrospective cohort will be created of patients who had undergone coronary CT angiography on prior CT scanner generations (with energy-integrating detector CT, EID-CT)

Treatment:

Diagnostic Test: Cardiac CTA on a regular CT with Energy-Integrating Detector (EID-CT)