Imagery Rescripting and Imaginal Exposure for Anxiety Symptoms

Hebrew University of Jerusalem

Status: Enrolling

Conditions: Social Anxiety; Panic; Generalized Anxiety; Obsessive-Compulsive Symptom

Treatments: Behavioral: Imagery rescripting for memories; Behavioral: Imaginal exposure for future events; Behavioral: Imagery rescripting for future events; Behavioral: Imaginal exposure for memories

Study type: Interventional

Funder types: Other

Identifiers

NCT05292807

isf2157/2021

Details and patient eligibility

About

This study will recruit 460 participants who self-report high symptoms of anxiety. Participants will be randomly assigned to one of 4 groups: one analog intervention of Imagery Rescripting (IR) for memories, an analog intervention of IR for future events, and analog intervention of Imaginal Exposure (IE) for memories and an analog intervention of IE for future events. We will examine the efficacy and mechanisms behind each intervention.

Full description

After being informed about the study potential risks, all patients giving written informed consent will undergo screening to determine eligibility for study entry. They will be randomly assigned to one of four conditions (Imagery rescripting past; Imagery rescripting future; Imaginal exposure past; Imaginal exposure future) at a 1:1:1:1 ratio (n = 115 per group). Participant will be assigned using a variance minimization method that controls for between group variance in continuous and categorical variables- SPIN, ASI-3, OCI-R, GAD-7 and gender with a completely random assignment p random = .2 (for algorithm see Sella et al., 2018). Participants will attend three ~1.5 hour online ZOOM sessions (baseline-assessment and measurement, intervention, post assessment and measurement and follow-up measurement).

In this multiple baseline study, participant will enter the intervention phase either 7 or 14 days after the baseline stage.

Assessors will be blind to the treatment condition.

Enrollment: 460 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

We will recruit participants based on attainment of SPIN score >= 24 and/or ASI-3 scores >=23 and/or OCI-R subscale scores (not including hoarding subscale) >=6 and/or GAD-7 scores >= 9 .

Exclusion criteria

Diagnosis of psychosis, active suicidality, post-traumatic stress disorder, acute stress disorder. Can't report a negative imagery related to a future social scenario. Attending active psychotherapy sessions. Started/stopped taking psychotherapeutic medications in the last 3 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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460 participants in 4 patient groups

Imaginal exposure for memories

Experimental group

Description:

A behavioral intervention in imagery for memories

Treatment:

Behavioral: Imaginal exposure for memories

Imaginal exposure for future events

Experimental group

Description:

A behavioral intervention in imagery for future events

Treatment:

Behavioral: Imaginal exposure for future events

Imagery rescripting for memories

Experimental group

Description:

A different behavioral intervention in imagery for memories

Treatment:

Behavioral: Imagery rescripting for memories

Imagery rescripting for future events

Experimental group

Description:

A different behavioral intervention in imagery for future events

Treatment:

Behavioral: Imagery rescripting for future events