Imaging 61CuATSM Uptake in Atherosclerotic Plaque Using PET-CT

King's College London

Status: Suspended

Conditions: Carotid Atherosclerosis

Treatments: Other: PET-CT with CuATSM

Study type: Observational

Funder types: Other

Identifiers

NCT01000181

EudraCT 2009-011476-30

GSTT Charity 251983

KCLADS09/1

Details and patient eligibility

About

The build up of plaque in the wall of the artery supplying blood to the brain poses a risk of stroke when the plaques become unstable and fragile. It is important to determine which patients are most at risk so that surgery can be performed. There is evidence that the risk is greatest when these plaques become oxygen deficient (hypoxic). The investigators wish to use PET imaging to identify hypoxic plaque, to help decide whether and when to perform surgery. The investigators have developed radiotracers (imaging agents) for this purpose, and this study is to determine whether they will work in patients.

Enrollment: 10 estimated patients

Sex: All

Ages: 55+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male/Female patients who are 55yrs or older and for whom carotid endarterectomy is clinically indicated and a decision has been made to perform a carotid endarterectomy.
• Normal liver and adequate renal function. Assessed by measuring eGFR (>50ml/min) and creatinine (<130μmol/L)
• Life expectancy > 12 weeks
• Patients should be able to tolerate head/neck mask as well as lying in the PET-CT scanner

Exclusion criteria

• Abnormal liver and renal function (eGFR <50ml/min, Creatinine >130μmol/L)
• Patient unwilling to provide written informed consent

Trial design

10 participants in 1 patient group

Patients undergoing carotid endarterectomy

Treatment:

Other: PET-CT with CuATSM