Imaging and Treatment Planning for Cardiac Radioablation (ITPCR)

Stewart Gaede

Status: Not yet enrolling

Conditions: Ventricular Tachycardia (V-Tach); Ventricular Tachycardia, Monomorphic; Ischemia, Myocardial

Treatments: Diagnostic Test: CT and MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT06938074

126882

Details and patient eligibility

About

Cardiac radioablation is a new treatment for ventricular tachycardia (VT), which uses beams of radiation to treat heart scar that causes VT. To identify the scar areas, magnetic resonance imaging (MRI) and computed tomography (CT) imaging are often used. These are both types of medical imaging that allow clinicians to examine scar area without having to do invasive surgery.

Researchers have developed new heart imaging protocols using both MRI and CT. Their MRI protocol method can now spot both dense and scattered scar tissue. The CT protocol combines multiple different types of scans into a single appointment and uses a special scanner that captures the motion of the heart. For this study, patients will undergo CT and MRI imaging according to these new imaging protocols.

With this study, researchers aim to show that these new imaging protocols can be undergone by patients with ventricular tachycardia and can be used to identify scar. Researchers will also use these scans to make radiation treatment plans to identify which types of treatment can be delivered safely to patients.

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Ischemic cardiomyopathy with monomorphic VT
• Referred by cardiologists
• 18 years of age or older Exclusion Criteria
• • Polymorphic ventricular tachycardia
• Ventricular fibrillation
• Pregnant or breastfeeding or planning to become pregnant or breastfeed during the study
• Estimated glomerular filtration rate ≤ 30 mL/min/1.73m2
• Previous allergic reaction to CT contrast agent Note that participants with contraindications for MRI can still be enrolled in this study but will not undergo MRI parts of this protocol.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

15 participants in 1 patient group

CT and MRI

Experimental group

Description:

All participants will undergo both CT imaging and MRI imaging to identify areas of ischemic scar. Treatment plans will be created based on CT scans, using various treatment delivery and motion management techniques.

Treatment:

Diagnostic Test: CT and MRI