Imaging and Understanding BOS in Lung Transplantation

Cincinnati Children's Hospital Medical Center

Status: Completed

Conditions: Bronchiolitis Obliterans Syndrome

Treatments: Drug: Hyperpolarized Helium-3 MRI

Study type: Observational

Funder types: Other

Identifiers

NCT02316392

2014-6004

Details and patient eligibility

About

This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years.

Full description

This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years. We will follow these patients at 6 months and 1 year with Hyperpolarized Helium-3 Magnetic Resonance Imaging and image guided bronchial biopsies to detect early BOS and to better understand BO disease progression. The biopsies will provide future research for rapid determination of cellular and molecular mechanisms that lead to BOS and to facilitate identification and validation of translatable pharmaceutical targets.

Enrollment: 6 patients

Sex: All

Ages: 1 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Lung Transplantation within the last 10 years or being assessed for possible lung transplantation.
• Male or female
• 0 to 25 years of age.

Exclusion criteria

• Standard MRI exclusion criteria as set forth by the CCHMC Division of Radiology
• Inability to perform 10 second breath hold for 3He MRI scan
• Bleeding disorders

Trial design

6 participants in 1 patient group

Post transplant subjects

Description:

Hyperpolarized Helium-3 MRI. Subjects who have had or are scheduled to have a lung transplant

Treatment:

Drug: Hyperpolarized Helium-3 MRI