Imaging-based, Non-invasive Diagnosis of Persistent Atrial Fibrillation (imATFIB)

County Clinical Emergency Hospital Cluj-Napoca

Status

Completed

Conditions

Atrial Fibrillation

Treatments

Diagnostic Test: Electrocardiography, ecocardiography and MRI.

Study type

Observational

Funder types

Other

Identifiers

NCT03584126

20117/04.10.2016

Details and patient eligibility

About

The main objective of the present project is to develop an imaging-based tool to determine the origin and cause of persistent atrial fibrillation (AF). The result of the study is a diagnostic method which aids the medical work-up of patients suffering from this disease.

Full description

Atrial fibrillation (AF) is the most common arrhythmia associated with substantial morbidity and mortality in humans. Histopathological studies of persistent AF have reported extracellular matrix remodeling with fibrotic infiltration which may cause atrial dilation. The degree of the fibrosis might have a significant impact on wave propagation during AF. The main objective of the present project is to develop an imaging-based tool to determine the origin and cause of persistent AF. The obtained clinical parameters of patients and controls (electrocardiography, ecocardiography and MR imaging data) will be correlated with known markers in order to identify novel markers for AF diagnosis.

Enrollment

123 patients

Sex

All

Ages

20 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

age: 20-80 years
weight: 50-120 kg
persistent, permanent or paroxysmal atrial fibrillation
clinically stable patients: outside of an acute cardiac event with constant chronic medication
optimum echographic window

Exclusion criteria

patients with: rheumatic mitral disease; acute myocardial-pericarditis; chronic rheumatism, under chronic or immunomodulatory treatment; infectious-inflammatory process of any cause
patients undergoing oncology treatment
patients under medication in another study
patients undergoing immunosuppressive therapy
contraindication for magnetic resonance imaging (MRI)
patients with valvular prosthesis, pacemaker of any type, metallic elements in the body (including metal particles accidentally in the body or as a result of exercising certain professions); pregnant patients; patients with known poly-allergy; patients with altered renal function (creatinine clearance <40 mL/min determined by the Cockcroft-Gault formula).