Imaging for the Evaluation of Transthyretin Cardiac Amyloidosis Prevalence of Patients Over 65 Hospitalized in Cardiology Wards (the IMPACT Study)

Poitiers University Hospital

Status and phase

Completed

Phase 3

Conditions

Transthyretin Cardiac Amyloidosis

Treatments

Procedure: Bony scintigraphy

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT05064839

2021-A00732-39

Details and patient eligibility

About

Heart failure with preserved ejection and hypertrophic cardiomyopathy are common diseases and often associated with transthyretin cardiac amyloidosis (TTR-CM), especially in elderly people. Nevertheless, research of TTR-CM is recommended in patients with ventricular hypertrophy without other cause such as valvular disease or hypertension. Therefore, the exact prevalence of TTR-CM remains unknown. We aim to determine the prevalence of TTR-CM in patients with ventricular hypertrophy and aged ≥ 60 years old, hospitalized in our cardiology department (CHU de Poitiers) by performing bone scintigraphy and research of AL amyloidosis.

Full description

Not Provided

Enrollment

553 patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient ≥ 60 years, hospitalised in cardiology wards of the Centre Hospitalier Universitaire of Poitiers
Left ventricle hypertrophy on echocardiography
Patient able to comply with study procedures
Patient legally free and not subject to any custody, guardianship, tutelage or subordination measures
Patient having signed an informed consent after clear and fair information on the study

Exclusion criteria

CardiacTransplant
Complex congenital cardiopathies
Know diagnosis of amylosis
Contra-indication to bony scintigraphy : hypersensitivity to sodium oxidronate or one of its excipients, or to one of the components of radiopharmaceutic marked product ;
Subject not able to comply with study procedures
Patients not benefiting from a Social Security scheme or not benefiting from it through a third party
Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, patients staying in a health or social establishment, adults under legal protection, and patients in emergency situation.
Women not menopausal