Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis

Turku University Hospital (TYKS)

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Pulmonary Sarcoidosis

Treatments: Drug: DOTANOC; Drug: Methionine

Study type: Interventional

Funder types: Other

Identifiers

NCT02824419

T16/2015

Details and patient eligibility

About

The goal of the current study is to evaluate the potential of the selected PET tracers to detect sarcoidotic lesions in lungs. The tracers are already in clinical use for the detection of certain inflammatory processes or malignant tumors, and their targets present similarities with molecular mechanisms of sarcoidosis.

Full description

The diagnosis of sarcoidosis is difficult since there is no specific noninvasive method available to diagnose sarcoidosis. FDG-PET imaging is in use, however, FDG is not a specific tracer for sarcoidosis and other inflammatory diseases may interfere with the imaging findings. The aim of the current protocol is to evaluate the potential of other inflammatory PET-tracers in the detection of sarcoidotic lesions.

The patients with active sarcoidotic lesions in lungs will be recruited. First, the patient undergoes PET-FDG scan and then the patient undergoes the PET scan either with C11-methionine or 68Ga-DOTANOC. The results with the latter tracers will be compared to the imaging results with FDG.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with sarcoidosis

Exclusion criteria

• any malignant disease
• any significant other inflammatory or infectious disease affecting lungs
• pregnancy

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

C11-methionine

Experimental group

Description:

To compare FDG and C11-methionine in the detection of sarcoidotic lesions.

Treatment:

Drug: Methionine

68Ga-Dotanoc

Experimental group

Description:

To compare FDG and 68Ga-DOTANOC in the detection of sarcoidotic lesions.

Treatment:

Drug: DOTANOC