Imaging of Atherosclerosis With 68Ga-MSA

Korea University

Status: Completed

Conditions: Noninvasive Imaging of Atherosclerosis; Atherosclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT01889693

GaMSA-Atherosclerosis

Details and patient eligibility

About

Despite of intensive efforts, no specific ath¬erosclerosis-targeting agent labeled with positron emitter is not yet available. Fortunately, some scientists made the major advance in the field of clinical atherosclerosis molecular imaging by the metabolic PET reporter agent 18F(fluorine-18)-FDG(Fludeoxyglucose) applied to noninvasively image plaque macrophages in carotid arteries. However, coronary and cerebral arterial segments remain uninterpretable due to metabolic property of 18F-FDG. Applying the character of the terminal mannose residues of MSA binding with the mannose receptors of macrophages in atherosclerosis, we investigate whether 68Ga-MSA can be a novel agent for non-invasive molecular imaging of atherosclerotic lesion in PET.

Enrollment: 60 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• acute coronary syndrome(acute myocardial infarction, unstable angina)
• chronic stable angina
• control without coronary artery disease

Exclusion criteria

• pregnancy, allergy to albumin, chronic inflammatory disease

Trial design

60 participants in 3 patient groups

acute coronary syndrome

Description:

patients with acute myocardial infarction and unstable angina

chronic stable angina

Description:

patients with chronic stable angina

control

Description:

control subjects without coronary artery disease