Imaging of High Grade Prostate Cancer

Ottawa Hospital Research Institute

Status

Terminated

Conditions

Prostatic Carcinoma

Treatments

Device: Imaging

Study type

Interventional

Funder types

Other

Identifiers

NCT02177526

Malignant Prostate 100

Details and patient eligibility

About

Management of prostatic carcinoma varies according to stage of disease. Trans-rectal ultrasound guided biopsy is known to underestimate the degree of tumor due to undersampling and random non-targeted technique. Methods to improve pre-operative tumor localization and grading, including multi-parametric (MP) magnetic resonance imaging (MRI) is an active area of research but requires further validation.

High grade tumors can undergo comedo-type necrosis with malignant calcifications which only occurs in Gleason pattern 5 tumors and which we hypothesize can be reliably detected using computed tomography (CT) and/or MRI.

Detection of malignant calcification within tumor foci will improve the accuracy of localization and grading in prostatic carcinoma.

Full description

High grade (Gleason pattern 5) tumors can undergo comedo-type necrosis producing malignant calcifications which we hypothesize can be reliably detected using computed tomography (CT) and/or MRI. Detection of malignant calcifications in areas of Gleason pattern 5 tumor will improve the accuracy of pre-operative localization and grading in prostatic carcinoma.

Enrollment

30 estimated patients

Sex

Male

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with malignant comedo-type necrosis and calcifications detected with histo-pathology from guided biopsies
Patients with biopsy proven Gleason pattern 5 tumor and without comedo-type necrosis associated calcification

Exclusion criteria