Imaging Studies in Corticobasal Syndrome (I-CAN)

Jennifer Whitwell

Status

Enrolling

Conditions

Corticobasal Syndrome (CBS)

Corticobasal Degeneration

Cortico Basal Degeneration

Corticobasal Degeneration (CBD)

Corticobasal Syndrome(CBS)

Corticobasal Syndrome

Treatments

Diagnostic Test: C-11 ER176 Radiotracer

Diagnostic Test: C-11 PiB

Diagnostic Test: AV1451 Tau

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT07000851

1R01AG087140-01A1 (U.S. NIH Grant/Contract)

24-007544

Details and patient eligibility

About

The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other. The investigator's will address our goal by using neuroimaging and blood plasma biomarkers, as well as molecular pathology.

Full description

Corticobasal syndrome (CBS) is a neurodegenerative disorder characterized by cognitive and behavioral change, as well as asymmetric parkinsonism, dystonia, myoclonus, and limb apraxia. Emerging evidence suggests neuroinflammation plays a key role in the pathogenesis of neurodegenerative disease, including the 4R tauopathies and AD, and neuroinflammation has been linked mechanistically to damage of the white matter. The primary goal of this study is to investigate inflammation and white matter damage using imaging and blood samples.

The investigator's will use the PET ligand 11C-ER176 to assess patterns of neuroinflammation in the brain and Neurite Orientation Dispersion and Density Imaging (NODDI) to measure white matter microstructure, including axonal density and alignment. The investigator's will also investigate blood plasma metrics, including neurofilament light chain and plasma glial fibrillary acidic protein (GFAP) that measure neuroaxonal injury and astrogliosis, and inflammation and tau metrics. The investigator's will employ beta-amyloid (A) and tau (T) PET to subdivide the CBS patients into those with biomarker AD (A+T+, CBS-AD) and those without biomarker AD (CBS-4R). The investigator's will also compare these groups to disease controls with typical amnestic biomarker AD (Amn-AD) and healthy controls (HC) that have previously been recruited for other grants (existing data collected under approved IRBs).

Enrollment

80 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 18 years or older
Meet possible or probable CBS criteria

Exclusion criteria

Subjects will be excluded if MRI is contraindicated (due to implanted device, severe claustrophobia, etc)
Subjects will be excluded if they have a concurrent illnesses or structural abnormality that could account for the CBS syndrome
Subjects will be excluded if they have a mutation in the progranulin gene
Subjects will excluded if they have received anti-Aβ therapy
Women who are pregnant will be excluded
Subjects will be excluded if they are actively taking daily anti-inflammatory medications (NSAIDs, corticosteriods, etc)
Subjects will be excluded if they have generalized inflammatory condition and treatment with immunosuppressive, corticoid/glucocorticoid, steroidal or non-steroidal anti-inflammatory medication within 2 weeks of scanning