Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) (MACOUPLING-CAD)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Completed

Conditions: CADASIL

Study type: Observational

Funder types: Other

Identifiers

NCT02071784

2014-A00200-47 (Registry Identifier)

C13-62

Details and patient eligibility

About

The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical models, the potential alterations of neurovascular coupling in CADASIL.

Full description

Comparison study of parameters derived from mathematical models of neurovascular coupling and obtained using fMRI (Bold signal, ASL and EEG).

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• CADASIL group: typical NOTCH3 mutation, age less than 60 years, rankin score at 0-1, active social insurance

Exclusion criteria

• MRI contra-indications and use of any treatment known to interfere with neurovascular coupling, pregnancy, lack of informed consent