Imaging the Colon Using a Colonoscope Compatible Imaging Probe

Mass General Brigham

Status: Begins enrollment this month

Conditions: Colon Polyps; Colonoscopy

Treatments: Device: Feasibility of using a CC-OCT probe to image the GI tract

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT07365436

1R01CA280972-01A1 (U.S. NIH Grant/Contract)

2025P001541

Details and patient eligibility

About

The goal of this study is to use a colonoscope compatible device capable of taking images of the lower gastrointestinal tract. The main question it aims to answer is:

Is the colonoscope compatible optical coherence tomography probe (CC-OCT probe) an effective device to use to take images of the gut?

During the participant's standard of care colonoscopy, the CC-OCT probe will be inserted into the colonoscope. The CC-OCT probe will then collect images of the participant's gastrointestinal tract in real time.

Enrollment: 250 estimated patients

Sex: All

Ages: 45 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 45 years of age or older
• Capable of giving informed consent
• Capable of following bowel prep instructions

Exclusion criteria

• 75 years of age or older
• Any contraindication to bowel prep or colonoscopy
• Current diagnosis of any bleeding disorders
• Currently using drugs that interfere with coagulation (excluding low-dose aspirin)
• Pregnancy

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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250 participants in 1 patient group

Undergoing Colorectal Screening

Experimental group

Description:

250 adult participants undergoing colorectal screening will be enrolled at MGH.

Treatment:

Device: Feasibility of using a CC-OCT probe to image the GI tract