Imaging the Dopamine Systems in Bulimia Nervosa

New York State Psychiatric Institute

Status: Completed

Conditions: Eating Disorders

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01493362

R01MH079397 (U.S. NIH Grant/Contract)

#5175

Details and patient eligibility

About

This study will use positron emission tomography imaging to investigate the dopamine systems in people with bulimia nervosa.

Enrollment: 33 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Participants with BN:

• Meets DSM-IV criteria for BN
• Sufficiently medically and psychiatrically stable to participate in research

Health Control Participants:

• No current or past psychiatric illness
• Between 80% and 120% of ideal body weight

Exclusion criteria

All participants:

• Current use of psychotropic medication such as anti psychotics or antidepressants
• Pregnant or breastfeeding
• history of substance abuse
• Significant medical illness
• High blood pressure (resting systolic blood pressure greater than 150mmHg and diastolic blood pressure greater that 90 mmHg)
• Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV
• Metal implants or paramagnetic objects contained within the body that may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to specified reference book guidelines
• Exposed to radiation in the workplace or has had a nuclear medicine procedure during the 1 year before study entry
• Previous adverse reaction to psycho stimulants

Trial design

33 participants in 2 patient groups

1

Description:

Participants with Bulimia Nervosa

2

Description:

Participants who are healthy controls