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Imatinib Discontinuation in Patients With Chronic Myeloid Leukemia Chronic Phase With Sustained MR4log

U

University of Sao Paulo General Hospital

Status

Unknown

Conditions

Leukemia, Myeloid, Chronic-Phase

Treatments

Other: imatinib discontinuation

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

This study will evaluate the proportion of subjects with chronic myeloid leukemia chronic phase that sustain major molecular response after imatinib discontinuation. To be eligible for this protocol, the subject must have received imatinib as first line regiment for at least 3 years with sustained molecular response of 4log (RM4log) or higher for one year.

Full description

Patients will be followed for 2 years, with molecular monitoring, every month in the first year and then every 2 months. Imatinib will be restarted if the major molecular response (RM3log) is lost during the study or if the subject withdraw the informed consenting.

The primary objective is to measure the number of subject that sustain the major molecular response (RM3log or BCR-ABL level below 0.1%) after 2 years of follow-up.

BCR: breakpoint cluster region

ABL: abelson murine leukemia

RM3log: major molecular response, BCR-ABL level below 0.1% (IS)

Enrollment

30 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Chronic myeloid leukemia chronic-phase, defined by the World Health Organization criteria
  • Treatment with imatinib for at least 36 months
  • BCR-ABL levels below 0,01% (IS) or MR4log in the last 12 months

Exclusion criteria

  • Previous allogeneic stem cell transplantation
  • Previous treatment with dasatinib, nilotinib, bosutinib or ponatinib
  • Imatinib dose escalation at any time, due to loss or inadequate response
  • BCR-ABL mutation

IS: International Scale

MR4log: molecular response of 4log or <0,1% (IS)

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

30 participants in 1 patient group

Discontinuation
Experimental group
Description:
All subjects will discontinue imatinib
Treatment:
Other: imatinib discontinuation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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