Immature Myeloid Cells in Respiratory Syncytial Virus Bronchioliltis

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Bronchiolitis

Treatments: Other: Respiratory secretions obtained

Study type: Observational

Funder types: Other

Identifiers

NCT01684527

0039-12-HYMC

Details and patient eligibility

About

The investigators hypothesize that Respiratory Syncytial Virus (RSV) infection may influence the population of lung immature myeloid cells and dendritic cells in a way that will impair their ability to invoke an effective immune response and lead to prolonged inflammation, angiogenesis and scarring. This may lead in turn to disturbed lung function.

Our aim is to determine the presence and phenotype of immature myeloid cells present in respiratory secretions of children with RSV bronchiolitis as compared to non-RSV bronchiolitis and healthy controls.

Enrollment: 55 estimated patients

Sex: All

Ages: Under 2 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Bronchiolitis

Exclusion criteria

• Chronic disease

Trial design

55 participants in 2 patient groups

Children Suffering From Bronchiolitis

Description:

Respiratory secretions obtained from children suffering from Bronchiolitis

Treatment:

Other: Respiratory secretions obtained

Healthy Children

Description:

Respiratory secretions obtained from children with no respiratory infection

Treatment:

Other: Respiratory secretions obtained