Immediate Implant Placement Using Xenograft Mixed with Vitamin D Versus Hyaluronic Acid.

Cairo University (CU)

Status: Enrolling

Conditions: Immediate Implant Placement

Treatments: Procedure: Vitamin D; Procedure: Hyaluronic Acid (HA)

Study type: Interventional

Funder types: Other

Identifiers

NCT06842368

A.M.A.E

Details and patient eligibility

About

Immediate implant placement using xenograft as space filling material mixed with vitamin D versus hyaluronic acid in posterior mandible region This study aims to evaluate implant stability and density after placement of immediate implant and Xenograft mixed with Hyaluronic acid or Vitamin D at posterior mandible region

Full description

Dental implants in fresh extraction sockets and healed sites have a erratic morphology, creating a wide space defect between the implant and buccal alveolar bone. This defect is critical for implant success, known as a jumping gap. Proper management of this space is essential for esthetic and functional success. Studies show adequate bone fill can be achieved in jumping gaps, but wider gaps increase implant body exposure risk.

The application of biological mediators embedded in the biomaterial can induce specific cell and tissue response, which can improve bone quality and quantity. Dental research has focused on improving bone substitutes by morphologic or bio- chemical modification.

Enrollment: 24 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Age: 18-60.

• Systemically healthy patients indicated for single or multiple immediate implants in posterior teeth region.
• Absence of any peri-apical pathosis.
• Patients with intact buccal plate of bone.
• Patients with adequate bone volume for the dental implant procedure.
• Patient with good oral hygrine

Exclusion criteria

• Heavy Smokers.
• Systemic disease that may affect the final outcome of the surgical procedure.
• No or poor patient's compliance.
• Patients with psychological problems.
• Pathology at the site of intervention.
• Patient with vit d deficiency

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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24 participants in 2 patient groups

Vitamin D mixed with Xenograft as space filling material after placement of immediate implant.

Experimental group

Description:

Careful extraction of the selected tooth will initiated using sharp periotome to sever the periodontal ligament attachments while preserving the surrounding alveolar bone and interdental papilla and followed by using extraction forceps. Meticulous mechanical debridement of the extraction socket will be carried out using bone curette to remove any soft tissue remnants or granulation tissue. All debris will washed out using copious saline irrigation. Implant osteotomy will then initiated engaging the furcation of the alveolus along with the remaining apical bone and while maintain jumping gap more than 2 mm between the implant platform and the alveolar. the jumping space will packed using Xenograft with particle size ranging from 0.25 to 1 mm and it will be mixed with Vitamin D and the socket will sealed using 4-0 resorbable sutures.

Treatment:

Procedure: Vitamin D

Hyaluronic acid mixed with Xenograft as space filling material after placement of immediate implant.

Active Comparator group

Description:

Careful extraction of the selected tooth will initiated using sharp periotome to sever the periodontal ligament attachments while preserving the surrounding alveolar bone and interdental papilla and followed by using extraction forceps. Meticulous mechanical debridement of the extraction socket will be carried out using bone curette to remove any soft tissue remnants or granulation tissue. All debris will washed out using copious saline irrigation. Implant osteotomy will then initiated engaging the furcation of the alveolus along with the remaining apical bone and while maintain jumping gap more than 2 mm between the implant platform and the alveolar. the jumping space will packed using Xenograft with particle size ranging from 0.25 to 1 mm and it will be mixed with hyaluronic acid and the socket will sealed using 4-0 resorbable sutures.

Treatment:

Procedure: Hyaluronic Acid (HA)