Immediate Versus Delayed FET Following a Stimulated IVF Cycle

ShangHai Ji Ai Genetics & IVF Institute

Status: Completed

Conditions: Fertilization in Vitro; Embryo Transfer

Treatments: Other: immediate frozen-thawed embryo transfer; Other: delayed frozen-thawed embryo transfer

Study type: Interventional

Funder types: Other

Identifiers

NCT03201783

ShangHaiIVG

Details and patient eligibility

About

Information regarding the optimal timing for frozen-thawed embryo transfer (FET) following a stimulated in vitro fertilization (IVF) is lacking. One option is to perform FET in the first cycle following the stimulated IVF cycle, i.e. immediate transfer. Another option is to postpone FET for at least one menstrual cycle, i.e. delayed transfer. This randomized study aims to compare the ongoing pregnancy rate of immediate versus delayed FET following a stimulated IVF cycle.

Enrollment: 724 patients

Sex: Female

Ages: 20 to 43 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women aged ≤43 years at the time of IVF/ICSI treatment Undergoing IVF with a standard stimulation At least one frozen embryo or blastocyst The first FET cycle following ovarian stimulation in IVF/ICSI

Exclusion criteria

• Use of mild stimulation or natural cycle for IVF/ICSI treatment Severe ovarian hyperstimulation syndrome during IVF/ICSI treatment Preimplantation genetic diagnosis treatment Use of donor oocytes Presence of hydrosalpinx which is not surgically treated or endometrial polyp on scanning during ovarian stimulation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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724 participants in 2 patient groups

immediate group

Other group

Description:

the intervention: immediate frozen-thawed embryo transfer (FET) which means FET will be performed in the first cycle following the stimulated IVF cycle

Treatment:

Other: immediate frozen-thawed embryo transfer

delayed group

Other group

Description:

the intervention: delayed frozen-thawed embryo transfer (FET) which means FET will be performed at least in the second cycle following the stimulated IVF cycle

Treatment:

Other: delayed frozen-thawed embryo transfer