Immune Benefits of Consumption of Dairy Yogurt in Elderly

Yonsei University

Status: Completed

Conditions: Immune Deficiency

Treatments: Dietary Supplement: Probiotic yogurt; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03051425

CI_immune

Details and patient eligibility

About

To investigate the impact of consuming dairy yogurt on immun function including natural killer (NK) cell activity, circulating levels of cytokines, and immunoglobulin (Ig) in elderly.

Full description

A randomized, open-labelled, placebo-controlled study was conducted on 200 nondiabetic, nonobese and elderly (≥60 years) subjects. Over a twelve-week period, the test group consumed one bottle (120 mL) of dairy yogurt each day, whereas the placebo group consumed same volume of low fat milk daily. NK cell activity (%) was measured based on the ratios of effector cells (E; peripheral blood mononuclear cells, PBMCs) from each participant to target cells (T; K562 cells) at E:T= 10:1, 5:1, 2.5:1, 1.25:1 or 0.625:1. In addition, cytokines and immunoglobulin levels measured using commercial kits as manufacturer's instruction.

Enrollment: 200 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Able to give informed consent
• Over 60 years old without any health problems
• The levels of white blood cells within range 4x10^3/μL~10x10^3/μL

Exclusion criteria

• Individuals who get a cold
• Diabetes
• Hypersensitivity or disease history for milk protein
• Epilepsy, neurological, or psychological disease
• Alcoholism or drug addiction
• Liver disease or severe kidney failure disease
• Inflammation-related disease
• Consumption of other test products or drugs within 1 month prior to screening
• Regular consumption of immune-related functional foods including yogurt or milk within 1 month prior to screening
• History of inflammation-related disease or taking medication to treat inflammation-related disease within 1 month prior to screening
• History of cancer within 5 years
• Any inappropriate condition

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups, including a placebo group

Test group

Experimental group

Description:

Probiotic yogurt supplementation

Treatment:

Dietary Supplement: Probiotic yogurt

Placebo group

Placebo Comparator group

Description:

Placebo supplementation

Treatment:

Dietary Supplement: Placebo