Immune Checkpoint Inhibitors and Pre-existing Autoimmune Diseases

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Advanced Cancer; Autoimmune Diseases

Treatments: Drug: Checkpoint inhibitor therapy

Study type: Observational

Funder types: Other

Identifiers

NCT03140137

CHECKAUTO

Details and patient eligibility

About

The tolerance of immune checkpoint inhibitors is unknown in patients with pre-existing autoimmune conditions. This retrospective nation-wide study will assess their tolerance in patients with pre-existing autoimmune conditions who received immune checkpoint inhibitors for an advanced cancer in clinical practice.

Enrollment: 112 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pre-existing autoimmune disease as diagnosed by the physician
• Immune checkpoint inhibitor therapy for an advanced cancer

Exclusion criteria

• Auto-immune disease developed only after the start of the immune checkpoint inhibitor therapy
• Absence of follow-up