Immune Mechanisms of Rejection in Human Lung Allografts

The Washington University

Status: Completed

Conditions: Bronchiolitis Obliterans

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00861900

HL056643

98-0977-201103312

Details and patient eligibility

About

The investigators have obtained compelling evidence that the development of anti-human leukocyte antigen (anti-HLA) antibodies against mismatched donor antigens significantly correlates with the development of bronchiolitis obliterans (BOS). Further, these anti-HLA antibodies are developed at least 15 months prior to any clinical evidence of BOS. This lag period between the development of anti-HLA antibodies and the onset of BOS gives us an opportunity to intervene to delay and/or prevent the development of BOS.

Enrollment: 778 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Lung transplant recipient.

Exclusion criteria

• Pregnant women,
• Prisoners, AND
• Anyone who is unable or unwilling to consent to this study.