Immune-modulatory Effect of Probiotic Strain on Grass Pollen Allergic Individuals

Nestlé

Status

Completed

Conditions

Seasonal Allergic Rhinitis

Treatments

Dietary Supplement: Probiotic

Dietary Supplement: Maltodextrin

Study type

Interventional

Funder types

Industry

Identifiers

NCT01660698

11.03.MET

Details and patient eligibility

About

The purpose of the current study is to evaluate the effect of administering a probiotic strain on allergic symptoms and immune parameters (Th-2 cytokines, effector cells) in seasonal allergic rhinitis subjects.

Full description

To identify immune markers in allergic individuals that are impacted by probiotic treatment during seasonal exposure

Enrollment

20 patients

Sex

All

Ages

20 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Confirmed allergy (allergic rhinitis) to grass pollen > 1 year and positive SPT > 3mm wheal diameter to grass pollen.
Age 20-65 years adults
Body Mass Index 19- 29 (people in the normal and overweight range)
Having obtained his/her informed consent.

Exclusion criteria

Anemia
Family history of congenital immunodeficiency
Regular consumption of immunosuppressive or anti-inflammatory treatment
Under medication against allergy (e.g. anti histaminic)
Avoid regular consumption of probiotic and other dietary nutritional interventions
Have a high alcohol consumption (more than 1 drink/day)
Consumption of illicit drugs
Pregnancy
- Subject who cannot be expected to comply with the study procedures, including consuming the test products
- Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study