Immune Profile of Acute VKH Patients PBMC (IPV)

Aier School of Ophthalmology, Central South University

Status: Unknown

Conditions: VKH Syndrome

Treatments: Drug: Steroids

Study type: Observational

Funder types: Other

Identifiers

NCT04025476

AFM1713D1

Details and patient eligibility

About

The investigators will collect blood samples of different courses of VKH patients for investigating immune profile, observe major immune cells number ,functional and membrane molecular changes in the course of treatment, to investigate pathogenesis of VKH. Meanwhile, the investigators will collect clinical data of VKH patients to observe choroid and retina change in different courses.

Enrollment: 48 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Acute VKH patients, meet a criterion of VKH, no recurrence.
2. Age range from 18 to 50 years old.

Exclusion criteria

1. Patients with Severe Cardiovascular and Cerebrovascular Diseases
2. Patients allergic to steroid or contrast agents;
3. A history of ocular trauma or intraocular surgery within 3 months; Vaccinated; History of infectious diseases
4. having a history of heredity, immune system correlation, neuroendocrine and digestive system diseases
5. Patients who take health care products for a long time and have heavy alcohol and tobacco addiction.

Trial design

48 participants in 2 patient groups

VKH patients

Description:

acute VKH patients

Treatment:

Drug: Steroids

control

Description:

health people age/sex match to the VKH patients