Immune Profiles and Circulating Tumor Cell Status Following Prostate Cryotherapy

National Taiwan University

Status: Unknown

Conditions: Clinical Corelation; Immune Profile; Prostate Cancer; Circulating Cancer Cells

Treatments: Procedure: Radiation; Procedure: Radical prostatectomy; Procedure: Prostate cryotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT01454037

201107059RB

Details and patient eligibility

About

The change of immune profiles and existence of circulating tumor cells following prostate cryotherapy may be correlated with the clinical outcome.

Enrollment: 160 estimated patients

Sex: Male

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age>20 years
• Histopathology-proven prostate adenocarcinoma
• Non-metastatic localized disease
• Subjects have chosen their curative, definitive treatments for prostate cancer prior to enrolling for the study
• Subjects are willing to sign the informed consent and agree to comply with the study procedures

Exclusion criteria

• Chronic use (> 2 weeks) of > 10 mg/day of prednisone or prednisolone within 2 months of the screening (topical or inhalational corticosteroids are permitted)
• Concurrent use of immunosuppressive therapy, including: cyclosporine, antithymocyte globulin, or tacrolimus within 3 months of study entry
• Other conditions the investigators think may affect subjects' compliance

Trial design

160 participants in 3 patient groups

Prostate cryoablation

Description:

Subjects receiving cryotherapy for prostate cancer

Treatment:

Procedure: Prostate cryotherapy

Radical prostatectomy

Description:

Subjects receiving radical prostatectomy

Treatment:

Procedure: Radical prostatectomy

Radiation

Description:

Subjects receiving radiation for prostate cancer

Treatment:

Procedure: Radiation