Immune Repertoire of Ovarian HGSC

Lei Li

Status: Unknown

Conditions: B Lymphocyte Receptor; T Lymphocyte Receptor; Immune Repertoire; Ovarian High Grade Serous Carcinoma

Treatments: Procedure: Treatment for ovarian cancer

Study type: Observational

Funder types: Other

Identifiers

NCT03794115

EOC-IMMUNE

Details and patient eligibility

About

In this preliminary study, peripheral blood and carcinoma tissue with pericarcinomatous tissue are taken from the patients with ovarian high grade serous carcinoma at several points: before any treatment, after the debulking surgery, and after all the proposed chemotherapy. The differential expression of the T/B lymphocyte receptors in these samples will be analyzed with the platinum-based treatment and survival outcomes of the patients. The primary objective is the expression rates of T/B lymphocyte receptors in different stages of checking points.

Enrollment: 40 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed of primary ovarian high grade serous carcinoma
• Aged 18 years or older
• No immunosuppressive disease
• Signed an approved informed consents

Exclusion criteria

• Not meeting all of the inclusion criteria