Immune Response After Booster Vaccination in HIV - Infected Patients Who Received Rabies Primary Vaccination

Queen Saovabha Memorial Institute

Status: Completed

Conditions: HIV; Rabies

Treatments: Biological: rabies vaccines on day 0 and 3

Study type: Interventional

Funder types: Other

Identifiers

NCT01286493

RC5303

Details and patient eligibility

About

Booster rabies vaccination in HIV - infected patients who have ever received rabies primary vaccination could improve their immune response to this kind of vaccine.

Full description

The investigators have learned from the previous studies that some HIV-infected patients especially those with low CD4+ T-lymphocyte count had poor antibody response to rabies vaccination. Because of the role of the memory B cell, the investigators hypothesized that primary rabies immunization in HIV-infected patients could rise rapid anamnestic antibody response to ones after booster vaccination in case of re-exposure of rabies occur despite of their immunocompromised state.

Enrollment: 33 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• HIV infected patients 18-60 years of age
• Ever received primary rabies immunization

Exclusion criteria

• currently have any active opportunistic infections
• have received blood or blood product within previous 3 months
• history of allergy to vaccine or any vaccine components
• currently received anti-malarial drugs

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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33 participants in 1 patient group

Rabies vaccines on day 0 and 3

Experimental group

Description:

Cell culture Rabies vaccines on day 0 and 3

Treatment:

Biological: rabies vaccines on day 0 and 3