Immune Response Features in Allergic Airway Diseases

Lithuanian University of Health Sciences

Status: Unknown

Conditions: Allergic Rhinitis; Allergic Asthma

Treatments: Procedure: Nasal provocation test

Study type: Observational

Funder types: Other

Identifiers

NCT04352088

AKTL1

Details and patient eligibility

About

This study aims to investigate immune mechanisms and phenotypes and endotypes of allergic airway diseases - allergic rhinitis and allergic asthma. Pathogenesis of these diseases are not fully investigated yet. Patients with the same disease have different dominant symptoms, course of the disease and response to treatment. Moreover, there is a hypothesis about united airway disease suggesting that allergic rhinitis and allergic asthma is different manifestation of the same disease. This led to assumption of phenotypes and endotypes. This classification which still is not unified can let to prescribe personalized treatment for every patient.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Hypersensitivity to house dust mites
• Allergic rhinitis with or without mild to moderate asthma

Exclusion criteria

• Acute or chronic infections
• Use of systemic immunosupresants (wait 1 month)
• Use of systemic or local antihistamines (wait 1 week)
• Use of intranasal steroids (wait 1 month)
• Oncological or active autoimmune diseases

Trial design

150 participants in 3 patient groups

Allergic rhinitis patients

Treatment:

Procedure: Nasal provocation test

Allergic rhinitis and asthma patients

Treatment:

Procedure: Nasal provocation test

Healthy individuals

Treatment:

Procedure: Nasal provocation test