Immune Response to Influenza Vaccination

NeuroTherapia, Inc.

Status: Completed

Conditions: Chronic Kidney Disease; Solid Organ Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT00551837

2006-12-14

Details and patient eligibility

About

The purpose of this study is to evaluate the immune response to a routine influenza vaccination. Influenza vaccination is given as part of routine standard of care in these individuals and is not part of the study protocol. The study will evaluate for a change in response to common antigens over time after influenza vaccination to determine if changes are related to the development of chronic rejection after solid-organ transplantation. We hypothesize that the influenza vaccine contributes to the alloreactivity of T cells verses common HLA types in the donor pool.

Enrollment: 82 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Transplant recipients (lung or kidney) 18 years or older, more than 3 months after transplantation
• Transplant candidates (kidney) 18 years or older, to recieve influenza vaccination
• Healthy volunteers to receive influenza vaccination

Exclusion criteria

• Under 18 years of age
• Pregnant
• Medical contraindication for vaccine
• Transplant recipients receiving acute rejection therapy within one month
• Healthy volunteers with autoimmune disease or medications to mediate immune function
• Receipt of live, attenuated influenza vaccine, instead of injectable vaccine