Immune Responses and Immunological Tolerance After Rabies Booster Vaccination in HIV-infected Adults

Queen Saovabha Memorial Institute

Status: Unknown

Conditions: Rabies

Treatments: Procedure: Blood drawn after rabies booster vaccination

Study type: Interventional

Funder types: Other

Identifiers

NCT03228069

1/2017

Details and patient eligibility

About

To study the humoral and cell-mediated immune responses in HIV-infected adults who had previously received rabies booster vaccination more than a year before

Full description

Previous study has shown the higher immunogenicity response among HIV-infected adults who received a single visit 4-site intradermal rabies booster vaccination than those who received the conventional intramuscular regimen. The investigators follow the persistence of these effects. Also, the regulatory T cell levels were examined after the rabies booster vaccination .

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Healthy HIV-infected adults
• Previously received rabies booster vaccination by participation in the previous clinical trials of the investigators.

Exclusion criteria

• Have any active opportunistic infections
• Received blood or blood product within 3 months
• Received anti-malarial drugs
• Received rabies vaccination in a previous year.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

single visit 4-site ID vaccination

Experimental group

Description:

Blood would be drawn from those who received a single visit 4-site ID rabies booster vaccination in the previous trial.

Treatment:

Procedure: Blood drawn after rabies booster vaccination

Conventional IM vaccination

Active Comparator group

Description:

Blood would be drawn from those who received a conventional intramuscular rabies booster vaccination in the previous trial.

Treatment:

Procedure: Blood drawn after rabies booster vaccination