Immune Responses to BCG Vaccination in Malawi and the UK

London School of Hygiene and Tropical Medicine

Status and phase: Completed; Phase 2

Conditions: Immunity, Cellular; Hypersensitivity, Delayed Type

Treatments: Biological: BCG

Study type: Interventional

Funder types: Other

Identifiers

NCT00241657

KPS10

Details and patient eligibility

About

BCG vaccination has been found to provide greater protection against TB in the UK than in Malawi. This study compares immune responses in BCG-vaccinated and unvaccinated teenagers and young adults in Malawi and in the UK.

Sex: All

Ages: 12 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BCG unvaccinated
• HIV negative
• Not pregnant
• Informed Consent

Exclusion criteria

• HIV positive
• Pregnant
• Seriously ill

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind