Immune Tolerance Dysfunction in Pregnancy Due to Ambient Air Pollution Exposure

Stanford University

Status: Completed

Conditions: Air Pollution; Pregnancy

Treatments: Other: There is no intervention

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04549142

IRB-56622

R01ES032253 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this project is to study the effects of air pollution toxicants on pregnant mothers' immune health during and after pregnancy.

Using already collected samples, this study proposes to evaluate changes in immune function in response to air pollution with the use of innovative technologies, to identify the drivers of immune dysfunction and potential modifiable factors, and to determine how these immune findings are associated with pollution exposure and outcomes of disease.

Enrollment: 400 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant women: at 18-25 weeks gestation at time of eligibility screening and baseline visit

Exclusion criteria

• Having smoked more than 50 cigarettes during pregnancy
• A history of autoimmune diseases, HIV or cancer

Trial design

400 participants in 4 patient groups

Pregnant women- high level pollution

Description:

Exposed to high levels of pollution (PM2.5)

Treatment:

Other: There is no intervention

Pregnant women- low level pollution

Description:

Exposed to low levels of pollution (PM2.5)

Treatment:

Other: There is no intervention

Non-pregnant women-high level pollution

Description:

Exposed to high levels of pollution (PM2.5)

Treatment:

Other: There is no intervention

Non-pregnant women-low level pollution

Description:

exposed to low levels of pollution (PM2.5)

Treatment:

Other: There is no intervention