Immune Treatment of Brain Metastasis of Lung Cancer Combined With Large-segmentation Precision Radiotherapy

H

Hunan Province Tumor Hospital

Status

Enrolling

Conditions

Non Small Cell Lung Cancer

Treatments

Radiation: radiotherapy
Drug: Chemotherapy + immunotherapy

Study type

Interventional

Funder types

Other

Identifiers

NCT05584267
RENO

Details and patient eligibility

About

This is a prospective multicenter clinical study. This study aims to construct an auxiliary decision-making system for lung cancer immunotherapy combined with radiotherapy by fusing three modes of imagomics, clinicopathological features, and molecular pathological features.

Enrollment

140 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age ≥ 18 years of age on day of signing informed consent
  • Histopathology confirmed non-small cell lung cancer
  • Asymptomatic brain metastases
  • EGFR/ALK ROS1 driver gene mutation negative
  • RECIST 1.1 based available assessment of lesions
  • ECOG 0-1
  • Brain metastases 1-4
  • Single lesion ≤4cm

Exclusion criteria

Patients with contraindication of chemotherapy Pregnant or breast feeding women

Trial design

140 participants in 3 patient groups

cohort A
Active Comparator group
Description:
Chemotherapy + immunotherapy; Every three weeks, up to four cycles of chemotherapy
Treatment:
Drug: Chemotherapy + immunotherapy
cohort B
Experimental group
Description:
Chemotherapy + immunotherapy; Once every three weeks, up to 4 cycles of chemotherapy; WBRT, 3 Gy/ time, 10 times in total
Treatment:
Drug: Chemotherapy + immunotherapy
Radiation: radiotherapy
cohort C
Experimental group
Description:
Chemotherapy + immunotherapy; Once every three weeks, up to 4 cycles of chemotherapy; HFRT, 10 Gy/ time, 3 times in total
Treatment:
Drug: Chemotherapy + immunotherapy
Radiation: radiotherapy

Trial contacts and locations

0

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Central trial contact

Yongchang C Zhang, MD; Nong C Yang, MD

Data sourced from clinicaltrials.gov

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