Immunity Markers in Intensive Care Patients and Ventilator-associated Pneumonia (IMMUNAIX)

Centre Hospitalier Intercommunal Aix-Pertuis

Status

Enrolling

Conditions

Pneumonia, Ventilator-Associated

Treatments

Diagnostic Test: Blood collection

Study type

Observational

Funder types

Other

Identifiers

NCT06607055

20232704-9

Details and patient eligibility

About

The goal of this observational study is to show the direct correlation between the occurrence of recurrence of VAP and postagressive immunoparalysis, monitored by HLA-DR rate below litterature-acknowledged threshold, in a well conducted antibiotherapy context, in patient admitted in the Intensive Care Unit.

The main questions it aims to answer are:

evaluation of the association between death and persistence of immunoplegia using HLA-DR monitoring
search an association between immunoplegia depth and severity of the initial state of shock
search an association between immunoplegia depth and viral reactivation
compare association of immunoplegia duration and HLA-DR nadir and VAP occurrence Blood samples will be taken from participants to HLA-DR dosage, at the time of inclusion and once a week then.

Full description

The occurrence of ICU-acquired infections in patients admitted to the intensive care unit (ICU) results in increased morbidity and mortality, increased length of stay in the ICU, and also clearly increased healthcare costs. The incidence of these infections fluctuates between 15% and 40%, depending on the study. A major problem in the ICU is the recurrence and relapse of ventilator-associated pneumonia (VAP), with increased exposure to antibiotics and a probable increase in average length of stay.

One of the possible hypothesis that could explain relapses/recurrences of VAP is incorrect conducted antibiotherapy. To prevent this, in the unit, we currently perform antibiotics pharmacological assays and adapt them to the antibiogram. Another possible explanation to treatment failure could be patients' postagressive immunoparalysis. It has clearly been demonstrated that postagressive immunoparalysis is a predisposing state to healthcare related infections.

Some markers can be used to monitor this immunoplegia state. Several studies have shown that low HLA-DR expression and reduced CD16 expression (polymorphonuclear neutrophils percentage) is associated with increased susceptibility to develop infections in the ICU.

Immunity monitoring could be an interesting tool to identify populations most at risk of developing healthcare-associated infections after a state of shock, and could become an interesting line of thinking for the use of immunomodulatory therapies. To best evaluate these therapies and find a place for them in the current arsenal, it is essential to integrate them into daily practice by linking them to a significant clinical event, such as recurrent healthcare-associated infections, despite properly conducted antibiotic treatment.

Enrollment

40 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient over 18 years old
Patient admitted in the Intensive Care Unit of the CHIAP
Patient under mechanical ventilation
Patient with infectious pneumonia
Informed Consent Form (ICF) obtained from the patient or emergency ICF obtained from close relatives
Patient beneficiary of French social security, whatever the regime

Exclusion criteria

Patient under 18 years old
Patient with severe neutropenia (neutrophils < 0.5 G/L)
Patient under immunosuppressive treatment
Use of corticosteroids (intravenous or oral) prior to ICU admission
Use of therapeutic antibodies
Onco-hematological disease (e.g. lymphoma, leukemia...) under treatment or treated in the 5 years prior to inclusion
End of chemotherapy 6 months prior to inclusion
Patients with innate or acquired immune deficiency (e.g., severe combined immunodeficiency, HIV or AIDS, at any stage)
Patients with a decision to limit or discontinue active therapies, at the time of inclusion
Patients with an estimated ICU stay of less than 48 hours
Participation in an interventional study
Patient deprived of their liberty
Patient under tutorship or curatorship
Pregnant or breastfeeding woman