Immunity to Measles Virus in the Thai Population Age 18-30 Years and Predictive Factors

Queen Saovabha Memorial Institute

Status: Unknown

Conditions: Measles

Study type: Observational

Funder types: Other

Identifiers

NCT01602094

TAI5501

Details and patient eligibility

About

Prevalence of participants who have protective immunity to measles virus is less than ninety percent.

Predictor of adequate measles antibody levels include the following :

• History of measles infection
• History of complete measles primary immunization( 2 doses with at least 1 month interval after age of 9 months)
• History of measles exposure

Predictor of inadequate measles antibody levels include the following :

• Born outside Thailand
• History of staying outside Thailand for long time in childhood
• Living in the rural area for a long period in childhood
• Fail to participate school system on time

Enrollment: 550 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-30 years old

Exclusion criteria

• Last measles vaccination less than 10 years of age
• Immunocompromised host including congenital immune defect, splenectomy or splenic dysfunction, history of suspect HIV exposure, taking immunosuppressant
• Receiving blood or blood product within 3 months
• Receiving others vaccinations or immunoglobulins or any medication that possibly decrease immune response

Trial design

550 participants in 2 patient groups

Adequate antimeales antibody levels

Description:

ELISA test OD \> 0.1

Inadequate measles antibody levels

Description:

ELISA test OD \< 0.1